Fat Loss Cream (Aminophylline 0.5% + glycrrhetinic acid 2.5%), Topical
Topically applied to fatty areas has been shown in human trials to significantly decrease fat thickness/circumference in 2 months. 60 ml
- delivered in an airtight, photo protective device. Our pharmaceutical devices dispense a metered dosage of the lotion
- use on face, under eyes, and body
- no colors, dyes, or perfumes with minimal preservatives
- usage protocols are sent on receipt of order
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notes: Fat Loss Cream applied to the skin works to decrease fat deposits. Clinical studies of 18 patients with daily thigh application of this cream for 1 month showed significant reductions in subcutaneous thigh fat. Vie’s prescription is the exact product and protocol to achieve these results.
Mechanism of action: Aminophylline inhibits alpha 2 adrenergic receptors (induced by estrogen) and inhibits phosphodiesterase to allow lipolysis to proceed. Glycyrrhetinic Acid is isolated from licorice root and blocks cortisol from reaching adipocytes (cortisol stops fat from being broke down).
Glycyrrhetinic acid, the active principle of licorice, can reduce the thickness of subcutaneous thigh fat through topical application.
Armanini D1, Nacamulli D, Francini-Pesenti F, Battagin G, Ragazzi E, Fiore C.
Cortisol is involved in the distribution and deposition of fat, and its action is regulated by the activity of 11beta-hydroxysteroid dehydrogenase.
Glycyrrhetinic acid, the active principle of licorice root, blocks 11beta- hydroxysteroid dehydrogenase type 1, thus reducing the availability of cortisol at the level of adipocytes. We evaluated the effect of topical application of a cream containing glycyrrhetinic acid in the thickness of fat at the level of the thigh. Eighteen healthy women (age range 20-33 years) with normal BMI were randomly allocated to treatment, at the level of the dominant thigh, with a cream containing 2.5% glycyrrhetinic acid (n=9) or with a placebo cream containing the excipients alone (n=9). Before and after 1 month of treatment both the circumference and the thickness of the superficial fat layer of the thighs (by ultrasound analysis) were measured. The circumference and the thickness of the superficial fat layer were significantly reduced in comparison to the controlateral untreated thigh and to control subjects treated with the placebo cream. No changes were observed in blood pressure, plasma renin activity, plasma aldosterone or cortisol. The effect of glycyrrhetinic acid on the thickness of subcutaneous fat was likely related to a block of 11beta- hydroxysteroid dehydrogenase type 1 at the level of fat cells; therefore, glycyrrhetinic acid could be effectively used in the reduction of unwanted local fat accumulation.