tesofensine KPV

KPV 500 mcg acid-resistant capsule- Anti-inflammatory for Psoriasis and Intestinal Bowel Disorder (IBD) ($3.25 per capsule best price)

$114.00$390.00

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KPV is a fragment of Alpha-MSH which has  shown some incredible anti-inflammatory capabilities. This is able to be driven across the  skin to help with healing, inflammatory  conditions, and treating psoriasis.   KPV is specially helpful with reducing dermatologic inflammation conditions such as psoriasis and intestinal issues particularly intestinal bowel disorder (IBD) and colon cancer.

KPV is a tri-peptide that targets inflammation. Inflammation is at the core of many uncomfortable problems. KPV acid-resistant capsule controls inflammation for an improved quality of life.  Most studies show improvement in dermatologic inflammatory conditions and in intestinal issues not responsive to routine therapy and medicines. The side effect profile is virtually the same as placebo.

KPV (Lysine-Proline-Valine) is a C-terminal tripeptide fragment of α-melanocyte stimulating hormone (α-MSH). α-MSH stimulates the production and release of melanin by melanocytes in skin and hair, acting through melanocortin 1 receptor.  Several studies have previously shown that KPV has decreased inflammation and tumorigenesis in the body. The KPV anti-inflammatory effect is PepT1-mediated in intestinal epithelial and immune cells. PepT1 is an oligopeptide transporter that is overexpressed in the colonic epithelial cells of chronic ulcerative colitis, which can deliver KPV into cytosol in the intestine. The tripeptide, KPV has significant antimicrobial and anti-inflammatory properties especially in those with psoriasis. Psoriasis is a chronic autoimmune condition which causes the rapid build-up of skin cells and is usually treated using hydrocortisone. In people with psoriasis, KPV has shown to limit symptoms of the condition including itchiness, dryness, redness, peeling, and more. Therefore, KPV could be used for an extended period of time without risking the unwanted complications of long term steroid therapy. KPV is a promising, therapeutic treatment for inflammatory bowel disease (IBD), colon cancer, and inflammatory skin disorders, in particular psoriasis.

 

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Product Details

Alpha-Melanocyte-Stimulating Hormone and Related Tripeptides: Biochemistry, Anti Inflammatory and Protective  Effects in Vitro and in Vivo, and Future Perspectives for the Treatment of Immune-Mediated Inflammatory Diseases 

Alpha-MSH is a tridecapeptide derived from proopiomelanocortin. Many studies over the last few years have provided evidence That Alpha -MSH has potent protective and antiinflammatory effects. These effects can be  elicited via centrally expressed melanocortin receptors that orchestrate descending neuro-genic antiinflammatory  pathways. Alpha-MSH can also exert antiinflammatory and protective effects on cells of the immune system and  on peripheral non immune cell types expressing melanocortin receptors. At the molecular level, Alpha-MSH affects  various pathways implicated in regulation of inflammation and protection, i.e., nuclear factor-B activation, expression of adhesion molecules and chemokine receptors, production of proinflammatory cytokines and mediators, IL-10 synthesis, T cell proliferation and activity, inflammatory cell migration, expression of antioxidative  enzymes, and apoptosis. The antiinflammatory effects of -MSH have been validated in animal models of experimentally induced fever; irritant and allergic contact dermatitis, vasculitis, and fibrosis; ocular, gastrointestinal,  brain, and allergic airway inflammation; and arthritis, but also in models of organ injury. One obstacle limiting the  use of alpha-MSH in inflammatory disorders is its pigmentary effect. Due to its preserved antiinflammatory effect  but lack of pigmentary action, the C-terminal tripeptide of -MSH, KPV, has been delineated as an alternative for  antiinflammatory therapy. KdPT, a derivative of KPV corresponding to amino acids 193–195 of IL-1, is also emerging  as a tripeptide with antiinflammatory effects. The physicochemical properties and expected low costs of production  render both agents suitable for the future treatment of immune-mediated inflammatory skin and bowel disease,  fibrosis, allergic and inflammatory lung disease, ocular inflammation, and arthritis.