Methylene Blue for Anti-Aging, Youthful Skin, Immune Boosting, Nootropic and Longevity 4mg Capsule ($1.30 per capsule best price)

$42.00 – $156.00

Methylene blue (MB), is a bioactive substance and a blue dye. It was FDA approved for its treatment of methemoglobinemia but has been used for decades for anti-aging, improving skin, immune boosting, improving memory, immunity, and arthritis. Methylene Blue has been shown to help with anti-aging benefits and is effective in stimulating skin fibroblasts. Methylene Blue helps with sirtuin activation which is one of the major way to help in anti-aging. Sirtuin activation is now being seen to be the main pathway to increase healthspan.

Methylene blue is a mitochondrial-targeting antioxidant. The mechanisms of mitochondrial targeted antioxidants, such as SKQ1, Coenzyme Q10, MitoQ, and Methylene blue, include increasing adenosine triphosphate (ATP) production, decreasing production of ROS and increasing antioxidant defenses, and providing benefits in neuroprotection following cerebral ischemia.

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Product Details

Mitochondria: Methylene blue is a mitochondrial-targeting antioxidant The mechanisms of mitochondrial targeted antioxidants, such as SKQ1, Coenzyme Q10, MitoQ, and Methylene blue, include increasing adenosine triphosphate (ATP) production, decreasing production of ROS and increasing antioxidant defenses, providing benefits in neuroprotection following cerebral ischemia.

Anti-Aging Potentials of Methylene Blue for Human Skin Longevity: Oxidative stress is the major cause of skin aging that includes wrinkles, pigmentation, and weakened wound healing ability. Application of antioxidants in skin care is well accepted as an effective approach to delay the skin aging process. Methylene blue (MB), a traditional mitochondrial-targeting antioxidant, showed a potent ROS scavenging efficacy in cultured human skin fibroblasts derived from healthy donors and from patients with progeria, a genetic premature aging disease. In comparison with other widely used general and mitochondrial-targeting antioxidants, we found that MB was more effective in stimulating skin fibroblast proliferation and delaying cellular senescence. The skin irritation test, performed on an in vitro reconstructed 3D human skin model, indicated that MB was safe for long-term use, and did not cause irritation even at high concentrations. Application of MB to this 3D skin model further demonstrated that MB improved skin viability, promoted wound healing and increased skin hydration and dermis thickness. Gene expression analysis showed that MB treatment altered the expression of a subset of extracellular matrix proteins in the skin, including upregulation of elastin and collagen 2A1, two essential components for healthy skin. Altogether, our study suggests that MB has a great potential for skin care.

Mitochondria is for:

• The flow of energy is the determining factor between life and death.

• Mitochondria sustain life and allostasis via energy transformation and signaling.

• Molecular, cellular, and behavioral responses to stress increase energy demand.

• Mitochondria produce hormones

Anti-Aging: In clinical trials we see that Methylene Blue treatment can help activate sirtuins. In one trial it increased NAD(+)/NADH ratio in hepatocytes, up-regulated SIRT1, and thereby decreased PGC-1α acetylation. In addition, hepatic mitochondrial DNA contents and oxygen consumption rates were enhanced. Methylene Bluetreatment also notably activated AMPK, CPT-1 and PPARα: the AMPK activation relied on SIRT1. Some researchers believe that it can also directly improve cellular and

Non-Peptide mitochondrial function and decrease the production of proteins linked to Alzheimer’s. It helps with dementia and has a host of other benefits in addition to dementia help. It is also being studied for its potential to inhibit monoamine oxidase (MAO), nitric oxide (NO) synthase, and guanylate cyclase.

Functional MR Imaging of the Effects of Methylene Blue in the Human Brain showed visible increases in cerebrovascular activity on the scans.