Zinc Thymulin + GHK-Cu (10 mcg/5mg /ml) 25ml Hair Regrowth Serum (Doses 25-50)
Zinc Thymulin with GHK-Cu serum is used to regenerate hair due to male pattern baldness. Zinc Thymulin can improve hair growth, can prevent hair loss in both men and females, and improve the quantity of hair. Hair growth with GHK-Cu is equivalent to Minoxidil without the headaches. GHK-Cu established itself as a powerful protective and regenerative ingredient for hair. GHK-Cu increases hair growth, thickness and enlarged follicle size.
Human studies show 32% increase in vellus hair and 23% increase in intermediate hair growth in “absent hair regions” in 6 months. Zinc-Thymulin with GHK-Cu serum blocks the DHT found in our scalp (the #1 culprit to hair loss), stimulates blood flow to support the follicles, and prolongs the growth cycle of hairs. It is possible to combine this with Valproic acid spray.
GHK-Cu is commonly used in hair transplant operations to increase the take of the grafts. In numerous human studies hair growth with GHK-Cu equalled that of minoxidil without the associated headaches that some people may experience.
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Thymulin is a nine amino acid peptide produced by two distinct epithelial populations in the thymus first described by Bach in 1977. It requires zinc for biological activity. The hormone is involved in T-cell differentiation and enhancement of T and NK cell actions. Thymulin has neuroendocrine effects as well. It follows a circadian rhythm and physiologically elevated ACTH levels correlate positively with thymulin plasma levels and vice versa. A recent study was done on Zinc Thymulin to test its efficacy in the treatment of hair loss. The study indicated that topical treatment with zinc thymulin significantly increased hair growth over 6 months; further, there were no systemic or local side effects from the treatment. The zinc thymulin metallo-peptide optionally also improves endogenous hair pigmentation. For example, by stimulating melanogenesis in grey or greying hair.
An Analysis of the Safety and Efficacy of Topical Zinc-Thymulin to treat Androgenetic Alopecia to assess the safety and efficacy of the metallopeptide zinc-thymulin (ZT) for treating androgenetic alopecia (AGA). Previous in vitro studies have described that different thymic peptides can both increase and decrease anagen (thymulin and thymosin beta-4, respectively). Zinc is an essential element and serum zinc deficiency can cause hair loss.
Eighteen consecutive adult subjects were recruited, 17 males and 1 female, age range 35-90 years(mean 55.4, SD 13.3) with a diagnosis of AGA, Norwood classification 2-7, and hair loss duration range of 3-40 years (mean 15.8, SD 9.6). The trial duration for each subject ranged from 4-10 months. The test compound ZT was synthesized by standard Fmoc peptide protocols and administered in water based topical spray to the scalp.Baseline and after treatment images for hair growth were graded by two blinded assessors using two validated scales: 1. numerical visual analog scale (VAS) for global assessment 2. hair growth index (HGI) of images under higher magnification for percentage changes of vellus, intermediate and terminal hair.
ZT demonstrated no adverse systemic effects or local side effects of redness or scalp irritation in any subject over a total of 3,300 treatment days. Three subjects who were concurrently using minoxidil (N=2) and minoxidil / finasteride (N=1) did not report any drug interaction with ZT. VAS hair assessment improvement was significant in subjects who completed 6 months of treatment (P=0.045, t-test). HGI assessment showed a significant increase in the number of newly observed intermediate hairs in previous “absent hair” regions (P<0.0001) with an average increase of vellus type (32%) and intermediate type (23%) hairs at 6 months. Melanogenesis was observed in several subjects. Topical applications of ZT demonstrated safety and established efficacy for initiating and maintaining anagen to treat male pattern baldness when applied for >6 months.
GHK-Cu is a naturally occurring copper complex that was first identified in humanplasma, but has hence been found in multiple locations such as saliva and urine. Copper peptides are small, naturally occurring protein fragments that have high affinity for copper ions, which are critical to normal body function. GHK-Cu has a variety of roles in the human body including, but not limited to, promoting activation of wound healing, attracting immune cells, antioxidant and anti-
inflammatory effects, stimulating collagen and glycosaminoglycan synthesis in skin fibroblasts, and promoting blood vessel growth. There has been evidence that has shown that it acts as a feedback signal that is generated after tissue injury. First, it seems to act as a potent protector of tissue and anti-inflammatory agent that controls the oxidative damage that occurs post-tissue injury. Further, it then plays a big role in signaling tissue remodeling which removes damaged/scarred tissue and generates new, healthy tissue. However, these positive effects decline with age because the concentration of GHK-Cu in the body decreases with age. Thus, there is an increase in inflammation, cancerous activity, and tissue destruction. Clinically, it is mostly used to decrease fine lines and wrinkles and to improve hair regrowth.